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A Clinic Study of Testosterone Propionate Treatmemt in Patients With Unstable Angina
Ma Jianfang,Zeng Aiping,Xie Dehui,Qiu Fengying,Zhang Ning,Chen Hong
Strategic Study of CAE 2003, Volume 5, Issue 4, Pages 70-72
To investigate effects of testosterone propionate on patients with unstable angina, testosterone propionateA conclusion can be drawn that testosterone propionate can significantly improve clinical symptoms and
Keywords： unstable angina testosterone propionate
Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Article
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
Engineering 2023, Volume 26, Issue 7, Pages 108-118 doi: 10.1016/j.eng.2022.10.020
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune system. Although the menstrual cycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated. To fill this gap, we profiled the plasma IgG N-glycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles (every 7 days for 3 months) using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC). We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in plasma. On the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait, with the highest being 1.1% for agalactosylated N-glycans. However, intrapersonal changes were relatively high in some cases; for example, the largest difference between theminimum and maximum values during themenstrual cycle was up to 21% for sialylated N-glycans. Across all measurements, the menstrual cycle phase could explain up to 0.72% of the variation in the abundance of a single IgG glycosylation trait of monogalactosylation. In contrast, up to 99% of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG N-glycosylation. In conclusion, the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small; thus, the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.
Keywords： N-glycosylation Immunoglobulin G Menstrual cycle Female sex hormones Estrogen Progesterone Testosterone
Title Author Date Type Operation
A Clinic Study of Testosterone Propionate Treatmemt in Patients With Unstable Angina
Ma Jianfang,Zeng Aiping,Xie Dehui,Qiu Fengying,Zhang Ning,Chen Hong
Journal Article
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